It is 11:30 pm on the night of my first chemotherapy infusion under the new diagnosis of LMBC (Liver Metastasized Breast Cancer), and everything went smashing well, if that is even possible. At least at this moment in time it seems so. But my eyes are WIDE OPEN, with no hint of sleep. I did get a bit groggy the last couple of miles on the drive home from the infusion, and then fell into a deep sleep for about an hour at 5pm. But what is really the culprit are the steroids they administer during the infusion.
In order to understand antimetabolites and how they work, it is necessary to briefly discuss the processes that are being targeted by these agents. The term metabolism refers to the many chemical reactions that take place in our bodies. We are constantly breaking down food into usable components and using those components to build our proteins, DNA and other cellular structures. Metabolite is a general term for the organic compounds that are synthesized, recycled, or broken down in cells. Materials that provide us with key metabolites enter our body as food. These compounds can be broken down into simpler structures that can be re-used in our cells. Examples include vitamins and amino acids. Metabolites that are the end products of a process or pathway may be excreted by the body. An example is urea, the end product of protein metabolism, excreted by the body as a component of urine.
Antimetabolites are structurally similar to metabolites, but they cannot be used by the body in a productive manner. In the cell, antimetabolites are mistaken for the metabolites they resemble, and are processed in the cell in a manner analogous to the normal compounds. The presence of the 'decoy' antimetabolites prevents the cells from carrying out vital functions and the cells are unable to grow and survive. Many of the antimetabolites used in the treatment of cancer interfere with the production of the nucleic acids, RNA and DNA.(1) If new DNA cannot be made, cells are unable to divide.
Usage: Carboplatin (Paraplatin®) is an alkylating agent used to treat a variety of cancers. Malignancies for which carboplatin is used include: Ovarian cancer, Germ cell tumors, Head and neck cancer, Small cell and non-small cell lung cancer, Bladder cancer, Relapsed and refractory (resistant to ordinary treatment) acute leukemia, endometrial cancer. Carboplatin is usually administered intravenously.
Mechanism: Carboplatin creates fragmented DNA, prevents DNA synthesis via cross-linking of DNA, and creates mutations in nucleotides.
During today's infusion, I felt a bit fuzzy headed, but nothing more really. Sarah and I were able to visit quietly, which was absolutely wonderful. She helped to get me scheduled for next week and for the next cycle of infusions in April. So all went very well. Sarah also got to meet our new car and chauffeur me home in it too. We nibbled on Biscotti for a snack during the drive. She stayed for just a moment and then scooted off to pick up her little guy at Nana's house.
We get the pleasure to spend time with both our daughters and their families tomorrow, and have the Barsun's for a sleepover, finally. We had to postpone the last two due to my new diagnosis and not feeling very well, and then the big storm last weekend.
|All the necessary supplies; ipad, knitting, water, medication lists, and my sweet Sarah visiting and taking the photo.|
AND a Cardiomyopathy warrior!!!
• I AM STRONG • I AM HEALTHY • I AM LOVED •